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It involves the collection of a patient's own blood from surgical sites which can be transfused back into the same person during or after surgery, as required. The authors undertook this systematic review to examine the evidence for the effectiveness of cell salvage in reducing the need for blood transfusions of donor blood in adults over 18 years undergoing surgery. The authors found 75 studies investigating the effectiveness of cell salvage in orthopaedic 36 studiescardiac 33 studiesand vascular 6 studies surgery.
Overall, the findings show that cell salvage reduces the need for transfusions of donated blood. The authors conclude that there appears to be sufficient evidence to support the use of cell salvage in cardiac and orthopaedic surgery.
Cell salvage does not appear to cause any adverse clinical outcomes.
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As the methodological quality of the trials was poor, the findings may be biased in favour of cell salvage. Background Concerns regarding the safety of transfused blood, have prompted reconsideration of the use of allogeneic blood from an unrelated donor red cell transfusion.
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The risks associated with volunteer donor blood transfusion allogeneic blood that has been screened by a competently managed modern laboratory are generally considered minimal, with the risks of human immunodeficiency virus HIV and hepatitis C HCV being extremely low Glynn ; Whyte However, of great concern is that in many developing countries there is a high prevalence of such infections and transfusion services are inadequately equipped to conduct universal antibody screening Lackritz ; McFarland The ramifications of such actions have been, in some cases, the elimination of a sizable proportion of blood donors from an already declining volunteer donor pool.
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Generally, such interventions fall into three groups: 1 the administration of agents to diminish blood loss e. Cell salvage is one technique that has been used extensively in the surgical setting. This review builds on the systematic review published by Huet et al Huet This review employs methods developed by the International Study of Perioperative Transfusion ISPOT study group a ten country study of evidence, attitudes and practices relating to the use of alternatives to allogeneic blood transfusion Fergusson b.
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Cell salvage for minimising perioperative allogeneic blood transfusion
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Corresponding author. This article is an update of " Cell salvage for minimising perioperative allogeneic blood transfusion.
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